Structure of PDB 6evj Chain F Binding Site BS01

Receptor Information

>6evj Chain F (length=746) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

SGMERIKELMEMVKNSRMREILTTTSVDHMAVIKKYTSGRQEKNPALRMK
WMMAMKYPISASSRIREMIPEKDEDGNTLWTNTKDAGSNRVLVSPNAVTW
WNRAGPVSDVVHYPRVYKMYFDRLERLTHGTFGPVKFYNQVKVRKRVDIN
PGHKDLTSREAQEVIMEVVFPNEVGARTLSSDAQLTITKEKKEELKNCKI
SPIMVAYMLERELVRRTRFLPIAGATSSTYVEVLHLTQGTCWEQQYTPGG
EAENDDLDQTLIIASRNIVRRSIVAIDPLASLLSMCHTTSISSEPLVEIL
RSNPTDEQAVNICKAALGIRINNSFSFGGYNFKRVKGSSQRTEKAVLTGN
LQTLTMTIFEGYEEFNVSGKRASAVLKKGAQRLIQAIIGGRTLEDILNLM
ITLMVFSQEEKMLKAVRGDLNFVNRANQRLNPMYQLLRHFQKDSSTLLKN
WGTEEIDPIMGIAGIMPDGTINKTQTLMGVRLSQGGVDEYSFNERIRVNI
DKYLRVRNEKGELLISPEEVSEAQGQEKLPINYNSSLMWEVNGPESILTN
TYHWIIKNWELLKTQWMTDPTVLYNRIEFEPFQTLIPKGNRAIYSGFTRT
LFQQMRDVEGTFDSIQIIKLLPFSAHPPSLGRTQFSSFTLNIRGAPLRLL
IRGNSQVFNYNQMENVIIVLGKSVGSPERSILTESSSIESAVLRGFLILG
KANSKYGPVLTIGELDKLGRGEKANVLIGQGDTVLVMKRKRDSSIL

Ligand information

>6evj Chain N (length=4)

gaau

....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6evj Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): I260 D304 F323 F357 E361 K376 F404 N429 Y432 S519 A521
• Binding residue (residue number reindexed from 1): I262 D306 F325 F359 E363 K378 F406 N431 Y434 S521 A523

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006370 7-methylguanosine mRNA capping
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0075526 cap snatching

Cellular Component

• GO:0033650 host cell mitochondrion
• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:6evj, PDBe:6evj, PDBj:6evj
• PDBsum: 6evj
• PubMed: 29202182
• UniProt: H6QM90