Structure of PDB 6ccv Chain F Binding Site BS01

Receptor Information

>6ccv Chain F (length=305) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

SADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKL
PVQQRRDMQWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQE
GNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMV
EVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISL
DQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAG
VVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVL
RDYLD

Ligand information

>6ccv Chain O (length=31)

gcttgacaaaagtgttaaattgtgctatact

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ccv Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
• Resolution: 3.05 Å
• Binding residue (original residue number in PDB): L178 N237 R239 L240 R268 K272 D274 K277 Y279 K280 S282 T283 Y284 T286 W287 W288 Q291 R295 R305 P307 V308 H309 R408 V436 T437 R440 Q443
• Binding residue (residue number reindexed from 1): L17 N76 R78 L79 R107 K111 D113 K116 Y118 K119 S121 T122 Y123 T125 W126 W127 Q130 R134 R144 P146 V147 H148 R247 V275 T276 R279 Q282

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0016987 sigma factor activity

Biological Process

• GO:0006352 DNA-templated transcription initiation
• GO:0006355 regulation of DNA-templated transcription
• GO:0010468 regulation of gene expression
• GO:2000142 regulation of DNA-templated transcription initiation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6ccv, PDBe:6ccv, PDBj:6ccv
• PDBsum: 6ccv
• PubMed: 30297823
• UniProt: A0QW02