Structure of PDB 6b6h Chain F Binding Site BS01

Receptor Information
>6b6h Chain F (length=497) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGIN
QVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDPNAENSIDPEL
AREKFAELRAQYVVTRDTIKAKGRSHATAQEEILKLSEVFKQFRLVPKQF
DYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWF
NAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMS
IGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAV
DKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRI
SRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDED
SHLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMRFGID
MNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLDD
Ligand information
>6b6h Chain 1 (length=88) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
taaaatgtgatctagatcacattttaggcaaaaaaggccttgacatccca
cctcacgtatgctataatgtgtgcagtctgacgcggcg
Receptor-Ligand Complex Structure
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PDB6b6h Structural basis of bacterial transcription activation.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R99 M102 M105 G106 L110 R385 L386 R397 K418 F419 E420 R423 Y425 K426 S428 T429 Y430 W433 W434 Q437 R441 R451 H455 M456 D581 T583 R586 K593
Binding residue
(residue number reindexed from 1)		R21 M24 M27 G28 L32 R269 L270 R281 K302 F303 E304 R307 Y309 K310 S312 T313 Y314 W317 W318 Q321 R325 R335 H339 M340 D465 T467 R470 K477
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6b6h, PDBe:6b6h, PDBj:6b6h
PDBsum6b6h
PubMed29146813
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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