Structure of PDB 5zgc Chain F Binding Site BS01

Receptor Information
>5zgc Chain F (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDPFFTLAKELYPGNY
KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFDIR
ADVMADPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTE
AVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEE
MRDLVQRETGKL
Ligand information
Receptor-Ligand Complex Structure
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PDB5zgc Crystal Structure of SIRT3 in complex with H4K16bhb peptide
Resolution2.9 Å
Binding residue
(original residue number in PDB)		F294 G295 E296 V324 E325 P326
Binding residue
(residue number reindexed from 1)		F112 G113 E114 V142 E143 P144
Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 N229 D231 H248
Catalytic site (residue number reindexed from 1) P35 D36 N75 D77 H94
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5zgc, PDBe:5zgc, PDBj:5zgc
PDBsum5zgc
PubMed
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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