Structure of PDB 5ola Chain F Binding Site BS01

Receptor Information

>5ola Chain F (length=989) Species: 9606 (Homo sapiens)

QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAV
MLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIE
RCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPP
VNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSV
EKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSL
YPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQ
RVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEALGAPEALREQPW
PLPVQMELGKLLAEMLVQATQMPCSLDRSSRLVPVLYHVYSFRNVQQIGI
LKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKL
MRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQL
FQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAR
EMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDV
ARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDD
ILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVH
QDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQD
AQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDF
PQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEW
VTPLGVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYR
KGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRF
CSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS

Ligand information

>5ola Chain G (length=21)

atggtgtaacgccagacgaac

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ola Mechanism of Transcription Anti-termination in Human Mitochondria.
• Resolution: 3.904 Å
• Binding residue (original residue number in PDB): Y1004 W1026 R1059 T1112
• Binding residue (residue number reindexed from 1): Y784 W806 R839 T871

Enzymatic activity

• Enzyme Commision number: 2.7.7.6: DNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003899 DNA-directed 5'-3' RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription

External links

• PDB: RCSB:5ola, PDBe:5ola, PDBj:5ola
• PDBsum: 5ola
• PubMed: 29033127
• UniProt: O00411|RPOM_HUMAN DNA-directed RNA polymerase, mitochondrial (Gene Name=POLRMT)