Structure of PDB 5nrl Chain F Binding Site BS01

Receptor Information
>5nrl Chain F (length=413) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPFEILPESIELFRTLALISPDRLSLSETAQILPKIVDLKRILQQQEIDF
IKLLPFFNEIIPLIKSNIKLMHNFLISLYSRRFPELSSLIPSPLQYSKVI
SILENENESDELFFHLENKAKLTREQILVLTMSMKTSFKNKEPLDIKTRT
QILEANSILENLWKLQEDIGQYIASKISIIAPNVCFLVGPEIAAQLIAHA
GGVLEFSRIPSCNIASIGKNKHLSHELHTLESGVRQEGYLFASDMIQKFP
VSVHKQMLRMLCAKVSLAARVDAGQKNGDRNTVLAHKWKAELSKKARKLS
EAPSISETKALPIPEDQPKKKRAGRKFRKYKEKFRLSHVRQLQNRMEFGK
QEQTVLDSYGEEVGLGMSNTSLQQAVGATSGSRRSAGNQAKLTKVMKHRI
SEANQQADEFLIS
Ligand information
>5nrl Chain 4 (length=114) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauug
uguuuuugcugguugaaauaauuauaacuccucauggucagacuauguag
ggaauuuuuggaau
Receptor-Ligand Complex Structure
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PDB5nrl Structure of a pre-catalytic spliceosome.
Resolution7.2 Å
Binding residue
(original residue number in PDB)		C257 N258 K264 K266 H267 R280 K300 R304 A308 L312 K340 P348 S351 K354 K366 R367 K371 F372 Y375 K376 K378 T438 K439
Binding residue
(residue number reindexed from 1)		C212 N213 K219 K221 H222 R235 K255 R259 A263 L267 K295 P303 S306 K309 K321 R322 K326 F327 Y330 K331 K333 T393 K394
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003723 RNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0005739 mitochondrion
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071011 precatalytic spliceosome
GO:0097526 spliceosomal tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nrl, PDBe:5nrl, PDBj:5nrl
PDBsum5nrl
PubMed28530653
UniProtP49704|PRP31_YEAST Pre-mRNA-processing factor 31 (Gene Name=PRP31)

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