Structure of PDB 5lqw Chain F Binding Site BS01

Receptor Information
>5lqw Chain F (length=218) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAKVQVKESELPSSIPAQTGLTFNIWYNKWSQGFAGNTRFVSPFALQPQL
HSGKTRGDNDGQLFFCLFFAKGMCCLGPKCEYLHHIPDEEDCFGREKFAD
YREDMGGIGSFRKKNKTLYVGGIDGAAQIESRIRFVFSRLGDIDRIRYVE
SKNCGFVKFKYQANAEFAKEAMSNQTLLLPSDKEWDDRREGTGLLVKDPD
PAAQKRLQEELKLESLNM
Ligand information
>5lqw Chain 6 (length=102) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacag
agaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagau
uu
...<<<<<<<.....>>>>>>>............................
..................<<.....>>.......................
..
Receptor-Ligand Complex Structure
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PDB5lqw Molecular architecture of the Saccharomyces cerevisiae activated spliceosome
Resolution5.8 Å
Binding residue
(original residue number in PDB)		P19 S20 G40 R46 F72 C73 F76 A77 N201 W212
Binding residue
(residue number reindexed from 1)		P12 S13 G33 R39 F65 C66 F69 A70 N174 W185
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017070 U6 snRNA binding
GO:0036002 pre-mRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0033120 positive regulation of RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
GO:0045787 positive regulation of cell cycle
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lqw, PDBe:5lqw, PDBj:5lqw
PDBsum5lqw
PubMed27562955
UniProtQ12046|CWC2_YEAST Pre-mRNA-splicing factor CWC2 (Gene Name=CWC2)

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