Structure of PDB 5iea Chain F Binding Site BS01

Receptor Information
>5iea Chain F (length=118) Species: 9544,262724 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKL
QTALEMLRQKQQEAETERNQVAALIARGKALGEQTQYMRELISELEHRLQ
GSMMDLLQGVDGIIKRIE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5iea Chain F Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5iea Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5 alpha.
Resolution3.258 Å
Binding residue
(original residue number in PDB)		C108 D111 H125 H128
Binding residue
(residue number reindexed from 1)		C14 D17 H31 H34
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K221
Catalytic site (residue number reindexed from 1) K115
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
6.1.1.11: serine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5iea, PDBe:5iea, PDBj:5iea
PDBsum5iea
PubMed27253059
UniProtP34945|SYS_THET2 Serine--tRNA ligase (Gene Name=serS);
Q0PF16|TRIM5_MACMU Tripartite motif-containing protein 5 (Gene Name=TRIM5)

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