Structure of PDB 5gq1 Chain F Binding Site BS01

Receptor Information
>5gq1 Chain F (length=173) Species: 39054 (Enterovirus A71) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRIEPVCLIIRGSPGTGKSLATGIIARAIADKYHSSVYSKQQVVTVMDDL
CDMSLFCQMVSTVDFIPPMASLAEGVSFTSKFVIASTRFYMDCDIEVTDS
YKTDLLDAGRAAKLCSENNTANFKRCSPLVCGKAIQLRDRKSKVRYSVDT
VVSELIREYSNRSAIGNTIEALF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5gq1 Chain F Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5gq1 Crystal structure of 2C helicase from enterovirus 71
Resolution2.493 Å
Binding residue
(original residue number in PDB)		C270 C286
Binding residue
(residue number reindexed from 1)		C115 C131
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:5gq1, PDBe:5gq1, PDBj:5gq1
PDBsum5gq1
PubMed
UniProtB9VUU3|POLG_HE71 Genome polyprotein

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