Structure of PDB 5gap Chain F Binding Site BS01

Receptor Information
>5gap Chain F (length=415) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFEILPESIELFRTLALISPDRLSLSETAQILPKIVDLKRILQQQEIDFI
KLLPFFNEIIPLIKSNIKLMHNFLISLYSRRFPELSSLIPSPLQYSKVIS
ILENENYSKNESDELFFHLENKAKLTREQILVLTMSMKTSFKNKEPLDIK
TRTQILEANSILENLWKLQEDIGQYIASKISIIAPNVCFLVGPEIAAQLI
AHAGGVLEFSRIPSCNIASIGKNKHLSHELHTLESGVRQEGYLFASDMIQ
KFPVSVHKQMLRMLCAKVSLAARVDAGQKNGDRNTVLAHKWKAELSKKAR
KLSEAPSISETKALPIPEDQPKKKRAGRKFRKYKEKFRLSHVRQLQNRME
FGKQEQTVLDSYGEEVGLGMSNTSLQQAVGATSGSRRSAGNQAKLTKVMK
HRISEANQQADEFLI
Ligand information
>5gap Chain V (length=67) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauug
uguuuuugcugguugaa
...................<<<<<.<<<.....<<<....>>>..>>>>>
>>>..............
Receptor-Ligand Complex Structure
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PDB5gap Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C257 N258 S261 K264 K266 H267 R280 Q281 K300 Q301 R304 A308 K309 K340 K343 P348 S351 K354 K365 R367 F372 Y375 K376 K378 F379 K436 T438 K439
Binding residue
(residue number reindexed from 1)		C215 N216 S219 K222 K224 H225 R238 Q239 K258 Q259 R262 A266 K267 K298 K301 P306 S309 K312 K323 R325 F330 Y333 K334 K336 F337 K394 T396 K397
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003723 RNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0005739 mitochondrion
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071011 precatalytic spliceosome
GO:0097526 spliceosomal tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gap, PDBe:5gap, PDBj:5gap
PDBsum5gap
PubMed26829225
UniProtP49704|PRP31_YEAST Pre-mRNA-processing factor 31 (Gene Name=PRP31)

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