Structure of PDB 5eh2 Chain F Binding Site BS01

Receptor Information
>5eh2 Chain F (length=109) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRHQR
THTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKSH
LLRHQRTHT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5eh2 Structural basis for human PRDM9 action at recombination hot spots.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		R726 F728 R736 H737 F756 H761 R764 H765 T768 R782 R785 N789 H793 T796 R810 N814 H817 R820 H821
Binding residue
(residue number reindexed from 1)		R9 F11 R19 H20 F39 H44 R47 H48 T51 R65 R68 N72 H76 T79 R93 N97 H100 R103 H104
Binding affinityPDBbind-CN: Kd=28nM
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
External links
PDB RCSB:5eh2, PDBe:5eh2, PDBj:5eh2
PDBsum5eh2
PubMed26833727
UniProtQ9NQV7|PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (Gene Name=PRDM9)

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