Structure of PDB 5c0c Chain F Binding Site BS01
Receptor Information
>5c0c Chain F (length=277) Species:
9606
(Homo sapiens) [
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MGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRA
PWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMY
GCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEA
AHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEA
TLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVV
PSGQEQRYTCHVQHEGLPKPLTLRWEP
Ligand information
>5c0c Chain H (length=10) Species:
9606
(Homo sapiens) [
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RQFGPDWIVA
Receptor-Ligand Complex Structure
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PDB
5c0c
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
Resolution
1.974 Å
Binding residue
(original residue number in PDB)
Y7 M45 E63 K66 V67 H70 D77 R97 Y99 H114 T143 K146 W147 Q155 L156 Y159 T163 W167 Y171
Binding residue
(residue number reindexed from 1)
Y8 M46 E64 K67 V68 H71 D78 R98 Y100 H115 T144 K147 W148 Q156 L157 Y160 T164 W168 Y172
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5c0c
,
PDBe:5c0c
,
PDBj:5c0c
PDBsum
5c0c
PubMed
27183389
UniProt
P04439
|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)
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