Structure of PDB 4v4i Chain F Binding Site BS01

Receptor Information

>4v4i Chain F (length=173) Species: 262724 (Thermus thermophilus HB27)

LPIPVPKGVSVEVAPGRVKVKGPKGELEVPVSPEMRVVVEEGVVRVERPS
DERRHKSLHGLTRTLIANAVKGVSEGYSKELLIKGIGYRARLVGRALELT
VGFSHPVVVEPPEGITFEVPEPTRVRVSGIDKQKVGQVAANIRAIRKPSA
YHEKGIYYAGEPVRLKPGKAGAK

Ligand information

>4v4i Chain w (length=2889)

ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguaccc
agaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggg
gaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgg
acaccgaauccccagccuagccgaagcuguugggaagcagcgccagagag
ggugaaagccccguaggcgaaagguggggggauaggugaggguacccgag
uaccccgugguucguggagccaugggggaaucugggcggaccaccgccua
aggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaag
gugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcu
uacaagcagucacggccccgcaagggguuguggcgugccuauugaagcau
gagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggc
guagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccg
aaaccgggcgagcuagcccuggccagggugaagcuggggugagacccagu
ggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcua
ggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaauga
cuuuagggucagccucaggcgcugacuggggccuguagagcacugauagg
gcuagggggcccaccagccuaccaaacccugucaaacuccgaaggguccc
agguggagccugggagugagggcgcgagcgauaacguccgcguccgagcg
cgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugg
uaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagc
cauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccg
aaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaug
accccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcg
agggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaa
agagggugagaaucccucucgccguaagcccaaggguuccuacgcaaugg
ucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagc
cgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggg
gacgcucuaggcuagggggaccggagccauggacgagcccggccagaagc
gcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggg
gaagcccguacgggugacaaccccccgaagccagggagccaagaaaagcc
ucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcg
ggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugc
aaguuggccccguaacuucgggagaaggggugcucccuggggugaugagc
uccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacaca
gcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggu
gccggaaggucaaggggaggggugcaagccccgaaccgaagccccgguga
acggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggg
uaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcg
agggacccggugaaauugaacuggccgugaagaugcggccuacccguggc
aggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuug
gucgcgccugcguaggauaggugggagccugugaacccccgccuccgggu
gggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaac
ccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgc
cuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaa
auccgccggagagcgcaaggguagaagggggccugacugcgaggccugca
agccgagcaggggcgaaagccgggccuagugaaccgguggucccgugugg
aagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugau
cucccccgagcguccacagcggcggggagguuuggcaccucgaugucggc
ucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgccc
auuaaagcggcacgcgagcuggguucagaacgucgugagacaguucgguc
ucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacga
gaggaccggaagggacgcaccucugguuucccagcugucccuccaggggc
auaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaag
cgggaagcccgccccaagaugaggccucccacggcgucaagccgguaagg
acccgggaagacgacccgguggaugggccggggguguaagcgccgcgagg
cguugagccgaccggucccaaucguccgaggucuugacc

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<......
..<<<<<<.[.[.((.>>>.....<<<<<<<..<<<)).].].>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<
<<<<<.....>>>>>>......<<<<<<.....<<....>>......>>>
>>.>.........<<....>>...<<<<<.....<<.....>>....>>>
>>...<<<.....<<<<<<<.....>>>>>>.>......<<<<<<<<...
..<<<...<<<<<.<<<..<<<....<<<<......>>>>.<<......(
(......>>.))...>>>....>>>.>>>>>...>>>.>>>>>.>>>...
..<<<...<<.........>>...>>>......<<<<<..<<<<>>>>>.
.>>>......>>.>>>>>>.>>...............<......>....>
>.........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<<<<<<<<....>>>>>>>>>>>................
..<<<<<<....<<<..<<<<<<<<..<<<...<<.......>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>>>>..>>>..<<.<
..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<
<<....>>>>><.<<<<<<<.....<<<<<<<<<...<<<...<<<<.<<
<.<.<<<<<<......>>>>.>>>..>>>.>>>>..>>.>...>>>>>>>
>>.....>>>>>>>..>..<<<<<<<.<<......>>.>>>>>>>.....
<<<......>>>...<<<<.<<<...<<<((......<<<<<<.......
....<<..<<.<<<<<.........<<<<<.<<...<<<<.......>>>
>...>>.......<.<<......>>.>.>>>>>.....>>>>>.>>.>>.
..........))......>>>>>>.>>>...>>>>>>><<<<<.<<....
.>>.>>>>>....>>>>>>.<<<<<<...<<.......<<<<<.<<<...
.>>>>>>>>....>>..>>>>>.>......>>>>>>.......<......
.<<<<<.......>>>>>.<<<<....<<<<..<<...<<<<<<...<<.
....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>
>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<....<<<.
...<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<
<<<<<<<<<<<<<<.<.......>>>>>>>>....>>>>>>>>>..>>>.
..<.<<......>>>......>>>>>...>>>..>>>>>.........>>
>....>>...>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.
<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........
......<<<<<...............>>>>><<<<<<<.<<<<.....>>
>>.>>>>>>>............<<<<<<<<<...<<.........>>...
<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<....
.<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>...
..>>><<<<<.........>>>>>....................<<<<<.
......>>>>>..........>>>>...>>.>>>>>>>.....>>.>>>>
>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<
.<<..<<......<<<<.<<<<<<..<<.<..<<<.<<<<<.<<<<...<
<<<<<<<<...........<<<<<..<<<<.....<<<<<<<<....>>>
>>>>>..>>>>............>>>>>..>>>>>>>>>...>>>>...<
<<<<....>>>>>....>>>>>.>>>...>.>>..<<<<.....>>>><<
<<<<...........>>>>>>..<<...<<<<<<....<<<<<<......
.>>>>>>.....<<...(((>>.....>>>>>>...<<<<..<<<.....
.>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>
..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...
<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<
..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>
>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....
>>...>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<........
.......>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>
>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>
>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<
<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>
>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v4i Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements
• Resolution: 3.71 Å
• Binding residue (original residue number in PDB): R59 S63 G66 L67 F109 Q139 G142 Q143 R149 H158 R170 K175 K179
• Binding residue (residue number reindexed from 1): R53 S57 G60 L61 F103 Q133 G136 Q137 R143 H152 R164 K169 K173

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v4i, PDBe:4v4i, PDBj:4v4i
• PDBsum: 4v4i
• PubMed: 16962654
• UniProt: P0DOY8|RL6_THET8 Large ribosomal subunit protein uL6 (Gene Name=rplF)