Structure of PDB 4tvx Chain F Binding Site BS01

Receptor Information
>4tvx Chain F (length=356) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKS
GYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSVD
KISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIRVNL
QQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFTAVD
DLQEQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHV
VHMLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGF
LQPSIQAFNQYWDRVANGYGLNGAAAQFSLSDVDPQVKQMPTLEQLKSWV
RNNGEA
Ligand information
>4tvx Chain L (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auaaaccgacgguauuguucagauccuggcuugccaacaggaguuccccg
cgccagcgggg
.............................................<<<<<
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Receptor-Ligand Complex Structure
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PDB4tvx Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli.
Resolution3.24 Å
Binding residue
(original residue number in PDB)		N19 R20 D21 K27 S40 Q42 S43 K45 R46 M166 F200 T201 V203 Q209 S211 A265 K266
Binding residue
(residue number reindexed from 1)		N18 R19 D20 K26 S39 Q41 S42 K44 R45 M162 F196 T197 V199 Q205 S207 A261 K262
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4tvx, PDBe:4tvx, PDBj:4tvx
PDBsum4tvx
PubMed25103409
UniProtQ46899|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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