Structure of PDB 4inh Chain F Binding Site BS01

Receptor Information
>4inh Chain F (length=167) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDKAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSI
AIHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPL
AVRMGAIASMRIQGRLVHGQSGMLLTGTIPGDCGAPYVHKRGNDWVVCGV
HAAATKSGNTVVCAVQA
Ligand information
Receptor-Ligand Complex Structure
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PDB4inh Structural basis of substrate specificity and protease inhibition in norwalk virus.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H30 I109 Q110 T134 P136 C139 A158 A159 A160 V168
Binding residue
(residue number reindexed from 1)		H33 I112 Q113 T128 P130 C133 A152 A153 A154 V162
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4inh, PDBe:4inh, PDBj:4inh
PDBsum4inh
PubMed23365454
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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