Structure of PDB 3rzu Chain F Binding Site BS01

Receptor Information
>3rzu Chain F (length=173) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLI
PKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHT
HCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKD
PPLFCSCSHVTVVDRAVTITDLR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3rzu Chain F Residue 11 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3rzu Structural and Thermodynamic Comparison of the Catalytic Domain of AMSH and AMSH-LP: Nearly Identical Fold but Different Stability.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H335 H337 D348
Binding residue
(residue number reindexed from 1)		H84 H86 D97
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0061578 K63-linked deubiquitinase activity
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination
GO:0070536 protein K63-linked deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:3rzu, PDBe:3rzu, PDBj:3rzu
PDBsum3rzu
PubMed21888914
UniProtO95630|STABP_HUMAN STAM-binding protein (Gene Name=STAMBP)

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