Structure of PDB 3jbo Chain F Binding Site BS01

Receptor Information
>3jbo Chain F (length=257) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKGIKKHLKRVNAPSHWMLNKMGGQYAPKTSSGPHKLLESIPLVILLRNR
LKYALTFDEVKMILIQKIVKVDNKVRTDCTFPVGLMDVIHITKSNEYFRL
LYDIKGRFVPHRITNEESKYKLCKVKKILLRKGRLSIAVTHDGRSIPYIH
PDVKVNDTVRLDLETGKVLEHLKFQVGSLVMVTAGHSVGRVGVISSIDKN
MGTYDIIHVKDSRNKVFATRLSNVFVIGDNTKPYISLPREKGIKLDIIEE
RRNRLKA
Ligand information
>3jbo Chain A (length=1608) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagcc
augcaagugaaaguauauauauauauauguagaaacugcgaacggcucau
uaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagc
uguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaa
uuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugacc
uaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaa
cggggaauuagaguucgauuccggagagggagccugagaaauagcuacca
caucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagaga
gguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaau
uuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagc
cgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaa
cgcucguaguugaauuucaaagaaucauucuuuuuaaaauccgauuuugu
uacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguu
ugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuugu
ucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucgu
auucagaugucagaggugaaauucuuagauuuucuggagacgaacaacug
cgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagg
gagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccga
cuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagu
cuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauu
gacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaac
acggggaaacucacuaguuuaagacauuggauggugaugcauggccguuu
uuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuu
aaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaa
cauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugaug
uccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgag
uaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuu
aucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaa
cgaggaaugccuaguaagcaugauucaucagauugugcuaacuacguccc
ugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaug
aauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucu
uuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcgga
aggaucau
...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<..<
.....<<<..<<..<<...<<<<..<.....<<.....<<<<<<.....>
>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<.....
.>.>>>>>>>..>....<<<.....>>>....>>>>..>>>>..>>>.<<
<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...
<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.
<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..
>>>..>....>>>.....<<<<<<<<...>>>>>>>>......<<<<<<.
........>>>>>>.........<<<<<((......<<<<.....<<..)
)>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((....
.<.<<...<<<.<<....<<<<.<....>.>>>>..<<<......>>><<
<<<<.<<.......<<...<.......>.<<<<.......<<<.>>>>>>
>...>>......>>.>>..>>>>.....<<<<<.<<.<.<<<.<......
....>.>>>.>.>>.>>>.>>.>>....<<<<<<..<<..<<<<<..<<<
.<<<<<<.<...<<<......>>>......>.>>>>>.>>>>......<<
<....>>>..>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<.
..<<...<<<<.........>>>>...>>>>>>>>..........<<<.<
<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>
.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<
<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<.......
.>>..........<<<<<<<....<<.>>...<<.<<<..<<<<<<<<..
...<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<
<.<<<.<<<...<<<<<<<<<<<<...>>>>>>>>>>>>...>>>>>>..
..<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>
>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<<.....<<
.<<<.<<<<<..>>>>>.>>.><<<.<<<<....>>>>.>>>....>>..
.....>>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<.<<<<<.<<<.
.<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>
>.>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>
>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3jbo Dynamical features of the Plasmodium falciparum ribosome during translation.
Resolution5.8 Å
Binding residue
(original residue number in PDB)
G2 K3 G4 I5 K6 K7 H8 K10 V12 N13 S16 M19 N21 K22 M23 G25 Q26 Y27 A28 P29 K30 S33 K37 L38 R49 T57 F58 D59 K62 I66 R77 K106 R108 K128 L131 R132 K133 G134 R135 V140 S146 Y149 K155 G186 H187 Y205 A219 R221 N224 R240 I248 R255
Binding residue
(residue number reindexed from 1)
G1 K2 G3 I4 K5 K6 H7 K9 V11 N12 S15 M18 N20 K21 M22 G24 Q25 Y26 A27 P28 K29 S32 K36 L37 R48 T56 F57 D58 K61 I65 R76 K105 R107 K127 L130 R131 K132 G133 R134 V139 S145 Y148 K154 G185 H186 Y204 A218 R220 N223 R239 I247 R254
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:3jbo, PDBe:3jbo, PDBj:3jbo
PDBsum3jbo
PubMed26432834
UniProtQ8IIU8

[Back to BioLiP]