Structure of PDB 3hx0 Chain F Binding Site BS01

Receptor Information
>3hx0 Chain F (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKATNHNLHITEKLEVLAKAYSVQGDKWRAAGYAKAINALKSFHKPVTSY
QEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGT
KTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIE
QTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSR
LLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPY
SEFACALLYFTGSAAFNASMRALAKTKGMSLSEHALSTAVVRNTHGAKVG
PGRVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hx0 Scrunching During DNA Repair Synthesis
Resolution3.0 Å
Binding residue
(original residue number in PDB)		W274 A277 S463 Q471 A514 R517 L527 S528 E529
Binding residue
(residue number reindexed from 1)		W28 A31 S217 Q225 A268 R271 L281 S282 E283
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D181 D183 D244
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3hx0, PDBe:3hx0, PDBj:3hx0
PDBsum3hx0
PubMed
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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