Structure of PDB 3hus Chain F Binding Site BS01

Receptor Information

>3hus Chain F (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGK
DCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGS
VDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELE
DWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSD
KFFTSHKGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQG
GTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTI

Ligand information

>3hus Chain I (length=4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GPRP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3hus Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and "A:a" interactions.
Resolution	3.04 Å
Binding residue (original residue number in PDB)	D301 F322 Q329 D330 K338 C339 H340 Y363 D364 R375
Binding residue (residue number reindexed from 1)	D200 F221 Q228 D229 K237 C238 H239 Y262 D263 R274

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005102	signaling receptor binding

	Biological Process
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0051258	protein polymerization

	Cellular Component
GO:0005577	fibrinogen complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3hus, PDBe:3hus, PDBj:3hus
PDBsum	3hus
PubMed	19650644
UniProt	P02679\|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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