Structure of PDB 3edl Chain F Binding Site BS01

Receptor Information

>3edl Chain F (length=421) Species: 9913 (Bos taurus)

RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMDSFNTFFSETGAGKH
VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIG
KEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDY
GKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYD
ICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVP
YPRIHFPLATYAPVISAEQLSVAEITNACFEPANQMVKCDPRHGKYMACC
LLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGG
DLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEG
EFSEAREDMAALEKDYEEVGV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3edl Chain F Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3edl Structure of the kinesin13-microtubule ring complex.
• Resolution: 28.0 Å
• Binding residue (original residue number in PDB): G144 T145
• Binding residue (residue number reindexed from 1): G133 T134
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:3edl, PDBe:3edl, PDBj:3edl
• PDBsum: 3edl
• PubMed: 19000825
• UniProt: Q2HJ86|TBA1D_BOVIN Tubulin alpha-1D chain (Gene Name=TUBA1D)