Structure of PDB 3e1i Chain F Binding Site BS01

Receptor Information

>3e1i Chain F (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQD
IANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFK
KNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNG
RTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFT
SHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYS
KASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT

Ligand information

>3e1i Chain H (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GHRP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3e1i Fibrinogen variant BbetaD432A has normal polymerization but does not bind knob "B".
Resolution	2.3 Å
Binding residue (original residue number in PDB)	F295 D297 D301 T305 F322 Q329 D330 C339 H340 Y363 D364
Binding residue (residue number reindexed from 1)	F190 D192 D196 T200 F217 Q224 D225 C234 H235 Y258 D259

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005102	signaling receptor binding

	Biological Process
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0051258	protein polymerization

	Cellular Component
GO:0005577	fibrinogen complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:3e1i, PDBe:3e1i, PDBj:3e1i
PDBsum	3e1i
PubMed	19075185
UniProt	P02679\|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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