Structure of PDB 3bvh Chain F Binding Site BS01

Receptor Information

>3bvh Chain F (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGK
DCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGS
VDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELE
DWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSD
KFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQG
GTYSKASTPNGYANGIIWATWKTRWYSMKKTTMKIIPFNRLTI

Ligand information

>3bvh Chain G (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GPRP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3bvh Polymerization-defective fibrinogen variant gammaD364A binds knob "A" peptide mimic.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	F295 D301 F322 Q329 K338 C339 H340 Y363
Binding residue (residue number reindexed from 1)	F194 D200 F221 Q228 K237 C238 H239 Y262

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005102	signaling receptor binding

	Biological Process
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0051258	protein polymerization

	Cellular Component
GO:0005577	fibrinogen complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3bvh, PDBe:3bvh, PDBj:3bvh
PDBsum	3bvh
PubMed	18642883
UniProt	P02679\|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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