Structure of PDB 2z4e Chain F Binding Site BS01

Receptor Information

>2z4e Chain F (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIAN
KGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNW
IQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTS
TADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHN
GMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKAS
TPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT

Ligand information

>2z4e Chain T (length=4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GHRP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2z4e Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini
Resolution	2.7 Å
Binding residue (original residue number in PDB)	F295 D297 T305 F322 Q329 D330 K338 C339 H340 Y363 D364
Binding residue (residue number reindexed from 1)	F187 D189 T197 F214 Q221 D222 K230 C231 H232 Y255 D256

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005102	signaling receptor binding

	Biological Process
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0051258	protein polymerization

	Cellular Component
GO:0005577	fibrinogen complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2z4e, PDBe:2z4e, PDBj:2z4e
PDBsum	2z4e
PubMed	17688324
UniProt	P02679\|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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