Structure of PDB 2vtb Chain F Binding Site BS01

Receptor Information

>2vtb Chain F (length=480) Species: 3702 (Arabidopsis thaliana)

HIHRVPALTEEEIDSVAIKTFERYALPSSSSVKRKGKGVTILWFRNDLRV
LDNDALYKAWSSSDTILPVYCLDPRLFHTTHFFNFPKTGALRGGFLMECL
VDLRKNLMKRGLNLLIRSGKPEEILPSLAKDFGARTVFAHKETCSEEVDV
ERLVNQGLKRVGNSTKLELIWGSTMYHKDDLPFDVFDLPDVYTQFRKSVE
AKCSIRSSTRIPLSLGPTPSVDDWGDVPTLEKLGVEPQEVTRGMRFVGGE
SAGVGRVFEYFWKKDLLKVYKETRNGMLGPDYSTKFSPWLAFGCISPRFI
YEEVQRYEKERVANNSTYWVLFELIWRDYFRFLSIKCGNSLFHLGGPRNV
QGKWSQDQKLFESWRDAKTGYPLIDANMKELSTTGFMSNRGRQIVCSFLV
RDMGLDWRMGAEWFETCLLDYDPCSNYGNWTYGAGVGNDPRYFSIPKQAQ
NYDPEGEYVAFWLQQLRRLMYMDTVVPLKH

Ligand information

>2vtb Chain L (length=4)

tttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2vtb Recognition and Repair of Uv Lesions in Loop Structures of Duplex DNA by Dash-Type Cryptochrome.
• Resolution: 2.01 Å
• Binding residue (original residue number in PDB): Y194 T195 R276 E325 W328 N391 R392 Q395 Y447 F448 S449 K452 Q453
• Binding residue (residue number reindexed from 1): Y192 T193 R274 E323 W326 N389 R390 Q393 Y442 F443 S444 K447 Q448

Enzymatic activity

• Catalytic site (original residue number in PDB): E325 W328 W356 N391 W409 W432
• Catalytic site (residue number reindexed from 1): E323 W326 W354 N389 W407 W430
• Enzyme Commision number: 4.1.99.3: deoxyribodipyrimidine photo-lyase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003904 deoxyribodipyrimidine photo-lyase activity
• GO:0003913 DNA photolyase activity
• GO:0005524 ATP binding
• GO:0009881 photoreceptor activity
• GO:0071949 FAD binding

Biological Process

• GO:0000719 photoreactive repair
• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006281 DNA repair

Cellular Component

• GO:0005739 mitochondrion
• GO:0009507 chloroplast

External links

• PDB: RCSB:2vtb, PDBe:2vtb, PDBj:2vtb
• PDBsum: 2vtb
• PubMed: 19074258
• UniProt: Q84KJ5|CRYD_ARATH Cryptochrome DASH, chloroplastic/mitochondrial (Gene Name=CRYD)