Structure of PDB 2j5t Chain F Binding Site BS01

Receptor Information
>2j5t Chain F (length=354) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGA
IAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQML
LTRADMEDRERFLNARDTLRALLDNNVVPVINENDAVATAEIKVGDNDNL
SALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIA
MSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLE
NRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVI
RICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDD
MITR
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain2j5t Chain F Residue 1371 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2j5t A Novel Two-Domain Architecture within the Amino Acid Kinase Enzyme Family Revealed by the Crystal Structure of Escherichia Coli Glutamate 5-Kinase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		G283 A284 G299
Binding residue
(residue number reindexed from 1)		G270 A271 G286
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.2.11: glutamate 5-kinase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004349 glutamate 5-kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:1901973 proline binding
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0016310 phosphorylation
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2j5t, PDBe:2j5t, PDBj:2j5t
PDBsum2j5t
PubMed17321544
UniProtP0A7B5|PROB_ECOLI Glutamate 5-kinase (Gene Name=proB)

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