Structure of PDB 2f9k Chain F Binding Site BS01

Receptor Information

>2f9k Chain F (length=343) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGK
YNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMD
SSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLI
ELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFY
LPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGK
IGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEE
LDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2f9k Chain F Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2f9k Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
Resolution	2.06 Å
Binding residue (original residue number in PDB)	D103 D107
Binding residue (residue number reindexed from 1)	D96 D100
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.

Gene Ontology

	Molecular Function
GO:0004659	prenyltransferase activity
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups

	Biological Process
GO:0008299	isoprenoid biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:2f9k, PDBe:2f9k, PDBj:2f9k
PDBsum	2f9k
PubMed	16892359
UniProt	P14324\|FPPS_HUMAN Farnesyl pyrophosphate synthase (Gene Name=FDPS)

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