Structure of PDB 2e2l Chain F Binding Site BS01

Receptor Information
>2e2l Chain F (length=317) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFLVAAIQFPVPIVNSRKDIDHNIESIIRTLHATKAGYPGVELIIFPEYS
TQGLNTAKWLSEEFLLDVPGKETELYAKACKEAKVYGVFSIMERNPDSNK
NPYNTAIIIDPQGEIILKYRKLFPWNPIEPWYPGDLGMPVCEGPGGSKLA
VCISHDGMIPELAREAAYKGCNVYIRISGYSTQVNDQWILTNRSNAWHNL
MYTVSVNLAGYYFGEGQICNFDGTTLVQGHRNPWEIVTGEIYPKMADNAR
LSWGLENNIYNLGHRGYVAKPGGEHDAGLTYIKDLAAGKYKLPWEDHMKI
KDGSIYGYPTTGGRFGK
Ligand information
Ligand IDARF
InChIInChI=1S/CH3NO/c2-1-3/h1H,(H2,2,3)
InChIKeyZHNUHDYFZUAESO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)N
CACTVS 3.341NC=O
ACDLabs 10.04O=CN
FormulaC H3 N O
NameFORMAMIDE
ChEMBLCHEMBL266160
DrugBank
ZINC
PDB chain2e2l Chain F Residue 3335 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2e2l Crystal structure of Helicobacter pylori formamidase AmiF reveals a cysteine-glutamate-lysine catalytic triad
Resolution2.29 Å
Binding residue
(original residue number in PDB)		E60 W137 S166 H167 Y192
Binding residue
(residue number reindexed from 1)		E48 W125 S154 H155 Y180
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) E60 N116 D122 P139 S166 Y192
Catalytic site (residue number reindexed from 1) E48 N104 D110 P127 S154 Y180
Enzyme Commision number 3.5.1.49: formamidase.
Gene Ontology
Molecular Function
GO:0004328 formamidase activity
GO:0016787 hydrolase activity
GO:0050126 N-carbamoylputrescine amidase activity
Biological Process
GO:0033388 putrescine biosynthetic process from arginine

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Molecular Function
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Biological Process
External links
PDB RCSB:2e2l, PDBe:2e2l, PDBj:2e2l
PDBsum2e2l
PubMed17307742
UniProtO25836|AMIF_HELPY Formamidase (Gene Name=amiF)

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