Structure of PDB 1p9u Chain F Binding Site BS01

Receptor Information
>1p9u Chain F (length=300) Species: 11149 (Transmissible gastroenteritis virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGLRKMAQPSGLVEPCIVRVSYGNNVLNGLWLGDEVICPRHVIASDTTRV
INYENEMSSVRLHNFSVSKNNVFLGVVSARYKGVNLVLKVNQVNPNTPEH
KFKSIKAGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYV
LENGILYFVYMHHLELGNGSHVGSNFEGEMYGGYEDQPSMQLEGTNVMSS
DNVVAFLYAALINGERWFVTNTSMSLESYNTWAKTNSFTELSSTDAFSML
AAKTGQSVEKLLDSIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGVN
Ligand information
Receptor-Ligand Complex Structure
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PDB1p9u Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
Resolution2.37 Å
Binding residue
(original residue number in PDB)		H41 T47 C144 H162 L164 E165 L166 G167 D186 Q187 S189 M190 Q191
Binding residue
(residue number reindexed from 1)		H41 T47 C144 H162 L164 E165 L166 G167 D186 Q187 S189 M190 Q191
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H41 G142 C144
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:1p9u, PDBe:1p9u, PDBj:1p9u
PDBsum1p9u
PubMed12746549
UniProtP0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab (Gene Name=rep)

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