Structure of PDB 1hr9 Chain F Binding Site BS01

Receptor Information
>1hr9 Chain F (length=443) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASQIPGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTA
HFLQHLAFKGTQNRPQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDI
PKAVDILSDILTKSVLDNSAIERERDVIIRESEEVDKMYDEVVFDHLHEI
TYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHE
KLVQYAQKYFGHVPKSESPVPLGSPRGPLPVFCRGERFIKENTLPTTHIA
IALEGVSWSAPDYFVALATQAIVGNWDRAIGTGTNSPSPLAVAASQNGSL
ANSYMSFSTSYADSGLWGMYIVTDSNEHNVRLIVNEILKEWKRIKSGKIS
DAEVNRAKAQLKAALLLSLDGSTAIVEDIGRQVVTTGKRLSPEEVFEQVD
KITKDDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ
Ligand information
>1hr9 Chain Q (length=8) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LSRVAKRA
Receptor-Ligand Complex Structure
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PDB1hr9 Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		Q73 Y102 T103 S104 E150 V154 W277 L286 F326 S327 E396
Binding residue
(residue number reindexed from 1)		Q54 Y83 T84 S85 E131 V135 W258 L267 F307 S308 E377
Enzymatic activity
Catalytic site (original residue number in PDB) H70 Q73 H74 E143 E150
Catalytic site (residue number reindexed from 1) H51 Q54 H55 E124 E131
Enzyme Commision number 3.4.24.64: mitochondrial processing peptidase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006627 protein processing involved in protein targeting to mitochondrion
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0017087 mitochondrial processing peptidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hr9, PDBe:1hr9, PDBj:1hr9
PDBsum1hr9
PubMed11470436
UniProtP10507|MPPB_YEAST Mitochondrial-processing peptidase subunit beta (Gene Name=MAS1)

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