Structure of PDB 1hr8 Chain F Binding Site BS01
Receptor Information
>1hr8 Chain F (length=443) Species:
4932
(Saccharomyces cerevisiae) [
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ASQIPGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTA
HFLQHLAFKGTQNRPQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDI
PKAVDILSDILTKSVLDNSAIERERDVIIRESEEVDKMYDEVVFDHLHEI
TYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHE
KLVQYAQKYFGHVPKSESPVPLGSPRGPLPVFCRGERFIKENTLPTTHIA
IALEGVSWSAPDYFVALATQAIVGNWDRAIGTGTNSPSPLAVAASQNGSL
ANSYMSFSTSYADSGLWGMYIVTDSNEHNVRLIVNEILKEWKRIKSGKIS
DAEVNRAKAQLKAALLLSLDGSTAIVEDIGRQVVTTGKRLSPEEVFEQVD
KITKDDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ
Ligand information
>1hr8 Chain Q (length=10) Species:
559292
(Saccharomyces cerevisiae S288C) [
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FFKPATRTLC
Receptor-Ligand Complex Structure
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PDB
1hr8
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
Q73 F77 N100 A101 Y102 T103 V154 E160 I180 W277 L286 A290 S327 S329 Q379 L380
Binding residue
(residue number reindexed from 1)
Q54 F58 N81 A82 Y83 T84 V135 E141 I161 W258 L267 A271 S308 S310 Q360 L361
Enzymatic activity
Catalytic site (original residue number in PDB)
H70 Q73 H74 E143 E150
Catalytic site (residue number reindexed from 1)
H51 Q54 H55 E124 E131
Enzyme Commision number
3.4.24.64
: mitochondrial processing peptidase.
Gene Ontology
Molecular Function
GO:0004222
metalloendopeptidase activity
GO:0005515
protein binding
GO:0008237
metallopeptidase activity
GO:0008270
zinc ion binding
GO:0046872
metal ion binding
Biological Process
GO:0006508
proteolysis
GO:0006627
protein processing involved in protein targeting to mitochondrion
Cellular Component
GO:0005739
mitochondrion
GO:0005759
mitochondrial matrix
GO:0017087
mitochondrial processing peptidase complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1hr8
,
PDBe:1hr8
,
PDBj:1hr8
PDBsum
1hr8
PubMed
11470436
UniProt
P10507
|MPPB_YEAST Mitochondrial-processing peptidase subunit beta (Gene Name=MAS1)
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