Structure of PDB 1hr6 Chain F Binding Site BS01

Receptor Information
>1hr6 Chain F (length=443) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASQIPGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTA
HFLEHLAFKGTQNRPQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDI
PKAVDILSDILTKSVLDNSAIERERDVIIRESEEVDKMYDEVVFDHLHEI
TYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHE
KLVQYAQKYFGHVPKSESPVPLGSPRGPLPVFCRGERFIKENTLPTTHIA
IALEGVSWSAPDYFVALATQAIVGNWDRAIGTGTNSPSPLAVAASQNGSL
ANSYMSFSTSYADSGLWGMYIVTDSNEHNVRLIVNEILKEWKRIKSGKIS
DAEVNRAKAQLKAALLLSLDGSTAIVEDIGRQVVTTGKRLSPEEVFEQVD
KITKDDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1hr6 Chain F Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1hr6 Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H70 H74 E150
Binding residue
(residue number reindexed from 1)		H51 H55 E131
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H70 E73 H74 E143 E150
Catalytic site (residue number reindexed from 1) H51 E54 H55 E124 E131
Enzyme Commision number 3.4.24.64: mitochondrial processing peptidase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006627 protein processing involved in protein targeting to mitochondrion
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0017087 mitochondrial processing peptidase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1hr6, PDBe:1hr6, PDBj:1hr6
PDBsum1hr6
PubMed11470436
UniProtP10507|MPPB_YEAST Mitochondrial-processing peptidase subunit beta (Gene Name=MAS1)

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