Structure of PDB 1gle Chain F Binding Site BS01

Receptor Information
>1gle Chain F (length=161) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLFDKLKSLVSTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGN
KMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGEGFKRIA
EEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVT
VGETPVIRIKK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1gle Chain F Residue 169 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1gle Cation-promoted association of a regulatory and target protein is controlled by protein phosphorylation.
Resolution2.94 Å
Binding residue
(original residue number in PDB)		H75 H90
Binding residue
(residue number reindexed from 1)		H68 H83
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.1.69: Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0016310 phosphorylation
GO:0034763 negative regulation of transmembrane transport
GO:0043610 regulation of carbohydrate utilization
GO:0045912 negative regulation of carbohydrate metabolic process
GO:1902344 negative regulation of maltose transport
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:1902495 transmembrane transporter complex
GO:1990154 enzyme IIA-maltose transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1gle, PDBe:1gle, PDBj:1gle
PDBsum1gle
PubMed8170944
UniProtP69783|PTGA_ECOLI PTS system glucose-specific EIIA component (Gene Name=crr)

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