Structure of PDB 9bdp Chain EF1A Binding Site BS01

Receptor Information
>9bdp Chain EF1A (length=430) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFK
YAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITG
TSQADCAILIIAGGVGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKM
DSVKWDESRFQEIVKETSNFIKKVGYNPKTVPFVPISGWNGDNMIEATTN
APWYKGWEKETKAGVVKGKTLLEAIDAIRPTDKPLRLPLQDVYKIGGIGT
VPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLEQGVPGDNVGFN
VKNVSVKEIRRGNVCGDAKNKGCASFNATVIVLNHPGQISAGYSPVLDCH
TAHIACRFDELLEKNDRRSGKKLEDHPKFLKSGDAALVKFVPSKPMCVEA
FSEYPPLGRFAVRDMRQTVAVGVIKSVDKT
Ligand information
>9bdp Chain A18S (length=1691) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagu
cgccgugccuaccauggugaccacgggugacggggaaucaggguucgauu
ccggagagggagccugagaaacggcuaccacauccaaggaaggcagcagg
cgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaaca
auacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauc
cuuuaacgaggauccauuggagggcaagucuggugccagcagccgcggua
auuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucgu
aguuggaucuugggagcggccguccccugcucggcgccggcccgaagcgu
uuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcag
cuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaac
ugaggccaugauuaagagggacggccgggggcauucguauugcgccgcua
gaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuug
ccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacga
ucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuu
uggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugac
ggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacg
ggaaaccucacccggcccggacacggacaggauugacagauugauagcuc
uuucucgauuccgugggugguggugcauggccguucuuaguugguggagc
gauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacua
guuacgcgaccccggucggcguaacuucuuagagggacaaguggcguuca
gccacccgagauugagcaauaacaggucugugaugcccuuagauguccgg
ggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgcc
ggcaggcgcggguaacccguugaaccccauucgugauggggaucggggau
ugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaag
cuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacua
ccgauuggaugguuuagugaggcccucggaucggccccgccgggccuggc
ggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaaguc
guaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<.....<<..........>>....>.>>......<<...
.....<<<.<....<<....<<<..........<<.....<<.<<<....
.>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<..<<
.>>.>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.
........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....
>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>
>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<
<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.........
..>..>>.........<<<<<((......<<<<.....<<..))>>....
...>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<..
.<<<.<<.....<<.<<<..>>>.>>.<<<<<<<.<<..>>>>>>.>>>.
<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......
>.>>>..>>>........<.<<.<<<<<<<...............>>>>>
>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...
<<<......>>>......>>>>>>>>..>>.......<<....>>...>>
>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.
<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<
<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>...
..>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<
<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>
..........<<<<<......<<<<<<.......<<.<<<........>>
>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<...
...>>...<<<......>>>...>>.>>>....<<<...<...<<<...<
<<<<<<<<<<<..>>>>.>>>>>>>>...>>>..>.....<<<<<.....
>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>
>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<
....>>>>.>>>....>.........>>>.>>............<<<<<.
.........>>>>>...........>>>>>.....<<<<<<<<.......
>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.
<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<..>>>>>
>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>
>.........<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9bdp Structural mechanism of angiogenin activation by the ribosome.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R37 G256 K288
Binding residue
(residue number reindexed from 1)		R32 G247 K279
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0043022 ribosome binding
GO:0051015 actin filament binding
GO:1904408 melatonin binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006409 tRNA export from nucleus
GO:0006412 translation
GO:0006414 translational elongation
GO:0006417 regulation of translation
GO:0006469 negative regulation of protein kinase activity
GO:0034198 cellular response to amino acid starvation
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0005856 cytoskeleton

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:9bdp, PDBe:9bdp, PDBj:9bdp
PDBsum9bdp
PubMed38718836
UniProtP02994|EF1A_YEAST Elongation factor 1-alpha (Gene Name=TEF1)

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