Structure of PDB 7ug7 Chain EF Binding Site BS01

Receptor Information
>7ug7 Chain EF (length=672) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKSAATTAFWSGMAKQ
YEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWR
QANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGANPVPLQLAIGAEEH
FTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAE
ASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVTCGSAFKNKGVQAM
LDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALAFKIATDP
FVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVR
AGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAVEPKTKADQ
EKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFN
VEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQYGHVVIDMYPLEPG
SNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRL
HFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENT
GDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRA
SYTMEFLKYDEAPSNVAQAVIE
Ligand information
>7ug7 Chain 16 (length=1514) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgaacgguaacagguuugcugacgaguggcggacgggu
gaguaaugucugggaaacugccugauggagggggauaacuacuggaaacg
guagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggc
cucuugccaucggaugugcccagaugggauuagcuaguaggugggguaac
ggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccac
acuggaacugagacacgguccagacuccuacgggaggcagcaguggggaa
uauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaaga
aggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguu
aauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacucc
gugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuac
ugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaaucccc
gggcucaaccugggaacugcaucugauacuggcaagcuugagucucguag
agggggguagaauuccagguguagcggugaaaugcguagagaucuggagg
aauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugc
gaaagcguggggagcaaacaggauuagauacccugguaguccacgccgua
aacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcg
uuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaa
uugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaa
cgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagauga
gaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagc
ucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauc
cuuuguugccagcgguccggccgggaacucaaaggagacugccagugaua
aacuggaggaagguggggaugacgucaagucaucauggcccuuacgacca
gggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcga
gagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaa
cucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccac
ggugaauacguucccgggccuuguacacaccgcccgucacaccaugggag
uggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccac
uuugugauucaugacuggggugaagucguaacaagguaaccguaggggaa
ccugcgguuggauc
........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<..<<<.....>>>>>..>>>>>......<<
.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>
>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>
>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<......
...>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>
.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.....
....<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.....
.<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<..
.....>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<
<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>........
..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<
<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<..
.<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>.
..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>
....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>....
......<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.
....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).
]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......
..>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>
>>>>...<<....>>..>>>>>.>...<<.<<<..<<<<<<.......<<
<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<
<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<....
.>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>
>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....
>>>...>>....>>>.....>>>>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<
<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...
>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....
>>>>>>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ug7 The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		P328 F329 V330 R359 R362 K507 S509 L591
Binding residue
(residue number reindexed from 1)		P300 F301 V302 R331 R334 K479 S481 L563
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ug7, PDBe:7ug7, PDBj:7ug7
PDBsum7ug7
PubMed35500116
UniProtP0A6M8|EFG_ECOLI Elongation factor G (Gene Name=fusA)

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