Structure of PDB 7zx0 Chain EEE Binding Site BS01

Receptor Information
>7zx0 Chain EEE (length=632) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIIRDDGFPIKGCDDT
LVVGLAVCWGGRDAYYFSLQKEQPPSLDPSLTLKDRMWYLQSCLRKESDK
ECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSI
VTSFLPHELPLLEGMETSSLGLNAGSEHSGRYRASVESILIFNSMNQLNS
LLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDA
IETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHPL
PGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRIT
FTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLELRI
LAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYG
IIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDG
FVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNI
QKQLETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQIV
KNEMESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zx0 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		A2238 T2243 F2244 T2245 N2248 G2388 M2393 G2394 S2397 R2448 Y2459 H2463 R2466 N2470 Q2474
Binding residue
(residue number reindexed from 1)		A345 T350 F351 T352 N355 G450 M455 G456 S459 R510 Y521 H525 R528 N532 Q536
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zx0, PDBe:7zx0, PDBj:7zx0
PDBsum7zx0
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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