Structure of PDB 7z4o Chain EEE Binding Site BS01

Receptor Information
>7z4o Chain EEE (length=615) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEELNKRSYLIRALTLNTMTKDAER
GKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGLPVGGNEKKAKLA
NVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWF
RNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAEMLANIDLKYFNK
STREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTK
TTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSY
INRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSVGVTVIKNN
MINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRAFELKKLWEQT
RSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPMNPFVS
HYDAVATTHSWIPKR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7z4o Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution3.412 Å
Binding residue
(original residue number in PDB)		H32 G33 T34 Y38 M356 R365
Binding residue
(residue number reindexed from 1)		H32 G33 T34 Y38 M323 R332
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7z4o, PDBe:7z4o, PDBj:7z4o
PDBsum7z4o
PubMed35605026
UniProtA0A024E3M6

[Back to BioLiP]