Structure of PDB 6tu5 Chain EEE Binding Site BS01

Receptor Information
>6tu5 Chain EEE (length=675) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITTKQRLNKRSYLIRALTLN
TIATPGMQIRGFVYFVEALARSICEKLEQSGLPVGGNEKKAKLANVVRKM
MTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSI
APIMFSNKMARLGKGYMFESKSMKLRTQVPAEMLANIDLKYFNKSTREKI
EKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWD
GLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGT
FEFTSFFYRYGFVANFSMELPSFGVSGINESADMSVGVTVIKNNMINNDL
GPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRAFELKKLWEQTRSKAGL
LVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPMNPFVSHKEEYD
AVATTHSWIPKREQMYQKCCNLFEKFFPPVGISSMVEAMVSRARIDARID
FESGRIKKEEFAEIMKICSTIEELR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6tu5 Chain EEE Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6tu5 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution3.325 Å
Binding residue
(original residue number in PDB)		G304 D305 D446 E491
Binding residue
(residue number reindexed from 1)		G265 D266 D407 E452
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tu5, PDBe:6tu5, PDBj:6tu5
PDBsum6tu5
PubMed32304664
UniProtM9TLW3

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