Structure of PDB 7tnq Chain E2 Binding Site BS01

Receptor Information
>7tnq Chain E2 (length=428) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MREVISIHVGQAGIQIGNACWELFCLEHGIQPDGQMPDAFNTFFSETGAG
KHVPRCVFLDLEPTVVDEVRTGTYRHLFHPEQLISGKEDAANNFARGHYT
IGKEIVDLSLDRIRKLADNCTGLQGFLMFNAVGGGTGSGLGCLLLERLSV
DYGKKSKLNFCSWPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAI
YDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDVTEFQTNL
VPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNSAFEPASMMAKCDPRH
GKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQP
PTVVPGGDLAKVMRAVCMISNSTAIAEVFSRMDHKFDLMYAKRAFVHWYV
GEGMEEGEFSEAREDLAALEKDYEEVGI
Ligand information
>7tnq Chain 17 (length=22) Species: 508771 (Toxoplasma gondii ME49) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PTLPFNAQSCYRSEYVAKPLPP
Receptor-Ligand Complex Structure
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PDB7tnq Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
Resolution8.4 Å
Binding residue
(original residue number in PDB)		E22 G29 I30 Q31 E77 G81 T82 T225
Binding residue
(residue number reindexed from 1)		E22 G29 I30 Q31 E68 G72 T73 T216
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tnq, PDBe:7tnq, PDBj:7tnq
PDBsum7tnq
PubMed35121661
UniProtP10873|TBA_TOXGO Tubulin alpha chain

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