Structure of PDB 9f43 Chain E Binding Site BS01

Receptor Information

>9f43 Chain E (length=1052) Species: 9606 (Homo sapiens)

EADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLN
VGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRA
RYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVF
NKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQEL
EVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKC
VSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLF
QKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWD
LAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQL
PIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSS
ARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRT
MTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGR
IWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAER
TDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVAL
QFISVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKFISATVQTGFCD
WSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGIT
RLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFH
NGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTA
WQGLSAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCV
TSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASL
QKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIA
CGSVNQFTAIYNSSGELINNIKYAISCLAFHPHWPHLAVGSNDYYISVYS
VE

Ligand information

>9f43 Chain G (length=9) Species: 9606 (Homo sapiens)

RVFFMDDVE

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9f43 mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR
• Resolution: 3.49 Å
• Binding residue (original residue number in PDB): R305 R306 D321 R338 L341 Q438 L440 L441 Q443 R446 Y475 K478 L479 S482 S483
• Binding residue (residue number reindexed from 1): R272 R273 D288 R305 L308 Q405 L407 L408 Q410 R413 Y442 K445 L446 S449 S450

External links

• PDB: RCSB:9f43, PDBe:9f43, PDBj:9f43
• PDBsum: 9f43
• PubMed: 39141345
• UniProt: Q8N122|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)