Structure of PDB 9f42 Chain E Binding Site BS01

Receptor Information

>9f42 Chain E (length=1052) Species: 9606 (Homo sapiens)

EADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLN
VGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRA
RYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVF
NKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQEL
EVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKC
VSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLF
QKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWD
LAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQL
PIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSS
ARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRT
MTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGR
IWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAER
TDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVAL
QFISVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKFISATVQTGFCD
WSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGIT
RLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFH
NGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTA
WQGLSAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCV
TSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASL
QKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIA
CGSVNQFTAIYNSSGELINNIKYAISCLAFHPHWPHLAVGSNDYYISVYS
VE

Ligand information

>9f42 Chain G (length=9) Species: 9606 (Homo sapiens)

RVFFMDDVE

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9f42 mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR
• Resolution: 3.27 Å
• Binding residue (original residue number in PDB): R305 D321 R338 L437 Q438 L440 L441 Q443 R446 P474 Y475 K478 L479 Q481 S482 S483
• Binding residue (residue number reindexed from 1): R272 D288 R305 L404 Q405 L407 L408 Q410 R413 P441 Y442 K445 L446 Q448 S449 S450

External links

• PDB: RCSB:9f42, PDBe:9f42, PDBj:9f42
• PDBsum: 9f42
• PubMed: 39141345
• UniProt: Q8N122|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)