Structure of PDB 9bs3 Chain E Binding Site BS01

Receptor Information

>9bs3 Chain E (length=487) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRD
IARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVL
AALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEV
PDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE
AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKL
PSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEF
LEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKK

Ligand information

>9bs3 Chain F (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gctgatgcgtg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9bs3 Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair.
Resolution	2.69 Å
Binding residue (original residue number in PDB)	G348 G350 G571 Q572 S588 R589 E592 F635
Binding residue (residue number reindexed from 1)	G88 G90 G311 Q312 S328 R329 E332 F375

External links

PDB	RCSB:9bs3, PDBe:9bs3, PDBj:9bs3
PDBsum	9bs3
PubMed	39159820
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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