Structure of PDB 8var Chain E Binding Site BS01

Receptor Information
>8var Chain E (length=334) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRWYPWLRPDFEKLVASYQAGRGHHALLIQALPGMGDDALIYALSRYLLC
QQPQGHKSCGHCRGCQLMQAGTHPDYYTLAPEKGKNTLGVDAVREVTEKL
NEHARLGGAKVVWVTDAALLTDAAANALLKTLEEPPAETWFFLATREPER
LLATLRSRCRLHYLAPPPEQYAVTWLSREVTMSQDALLAALRLSAGSPGA
ALALFQGDNWQARETLCQALAYSVPSGDWYSLLAALNHEQAPARLHWLAT
LLMDALKRHHGAAQVTNVDVPGLVAELANHLSPSRLQAILGDVCHIREQL
MSVTGINRELLITDLLLRIEHYLQPGVVLPVPHL
Ligand information
Receptor-Ligand Complex Structure
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PDB8var Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		G89 V90 R94 T121 T304
Binding residue
(residue number reindexed from 1)		G89 V90 R94 T121 T304
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0009360 DNA polymerase III complex
GO:0030894 replisome
GO:0043846 DNA polymerase III, clamp loader complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8var, PDBe:8var, PDBj:8var
PDBsum8var
PubMed38490435
UniProtP28631|HOLB_ECOLI DNA polymerase III subunit delta' (Gene Name=holB)

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