Structure of PDB 8vaq Chain E Binding Site BS01

Receptor Information
>8vaq Chain E (length=337) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMRWYPWLRPDFEKLVASYQAGRGHHALLIQALPGMGDDALIYALSRY
LLCQQPQGHKSCGHCRGCQLMQAGTHPDYYTLAPEKGKNTLGVDAVREVT
EKLNEHARLGGAKVVWVTDAALLTDAAANALLKTLEEPPAETWFFLATRE
PERLLATLRSRCRLHYLAPPPEQYAVTWLSREVTMSQDALLAALRLSAGS
PGAALALFQGDNWQARETLCQALAYSVPSGDWYSLLAALNHEQAPARLHW
LATLLMDALKRHHGAAQVTNVDVPGLVAELANHLSPSRLQAILGDVCHIR
EQLMSVTGINRELLITDLLLRIEHYLQPGVVLPVPHL
Ligand information
Receptor-Ligand Complex Structure
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PDB8vaq Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K85 T87 G89 V90 R94 G305
Binding residue
(residue number reindexed from 1)		K88 T90 G92 V93 R97 G308
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0009360 DNA polymerase III complex
GO:0030894 replisome
GO:0043846 DNA polymerase III, clamp loader complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vaq, PDBe:8vaq, PDBj:8vaq
PDBsum8vaq
PubMed38490435
UniProtP28631|HOLB_ECOLI DNA polymerase III subunit delta' (Gene Name=holB)

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