Structure of PDB 8uw1 Chain E Binding Site BS01

Receptor Information
>8uw1 Chain E (length=91) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQE
ASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Ligand information
>8uw1 Chain I (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcgagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacggattctcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcagatatatacatccgat
Receptor-Ligand Complex Structure
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PDB8uw1 Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		T45 R63 R72 R83 F84 V117 T118
Binding residue
(residue number reindexed from 1)		T1 R19 R28 R39 F40 V73 T74
External links
PDB RCSB:8uw1, PDBe:8uw1, PDBj:8uw1
PDBsum8uw1
PubMed39196936
UniProtP84233|H32_XENLA Histone H3.2

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