Structure of PDB 8tw9 Chain E Binding Site BS01

Receptor Information
>8tw9 Chain E (length=1124) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKD
IDQIPGRVGWLTNMHATLVSGISGVDFYFLDEEGGSFKSTVVYDPYFFIA
CNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLS
FVNSNQLFEARKLLRPILQDNANNDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
KAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETF
PNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVERE
AIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEA
KKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQ
MARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSM
LNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSK
EEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEG
DTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEY
EGQKSTSITTARRLGDFLDKGLQCKYIISSKPFNAPVTERAIPVAIFSAD
IPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQ
GVSNPVPRVEHPDWLKRKIATKED
Ligand information
>8tw9 Chain C (length=26) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TVKIWVKYNEGFSNAVRKNVTWNNLW
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tw9 Cryo-EM reveals that Ctf18-RFC collaborates with PolE to load the PCNA clamp onto a leading strand DNA
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E336 I452 Q993 N997 L1037 E1038 D1041
Binding residue
(residue number reindexed from 1)		E277 I393 Q934 N938 L978 E979 D982
External links
PDB RCSB:8tw9, PDBe:8tw9, PDBj:8tw9
PDBsum8tw9
PubMed
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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