Structure of PDB 8tas Chain E Binding Site BS01

Receptor Information
>8tas Chain E (length=570) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQ
PVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPL
QQNFMVHGDRECGFINDEIFVELVNALGQYSDKIFEAISSMFPDKGTAEE
LKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRC
FKYDCFLHFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTP
PENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSI
IAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHP
RQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLA
VRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGI
FIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVD
ATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY
RYSQADALKYVGIEREMEIP
Ligand information
>8tas Chain T (length=193) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccgtcagacgctgcgccgccggcggccggagaatcccggtgccgaggcc
gccctattggtcgtagacagccccagcaccgcctaaacgcacgtacgcgc
cgtcccccgcgttttaaccgccaaggggattaccccccagtccccaggca
cgtgccagatatatacatcccgtacgcacgcacatcattcgat
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tas Activation of automethylated PRC2 by dimerization on chromatin
Resolution4.1 Å
Binding residue
(original residue number in PDB)		K500 R502 C567 K568 A569 Q575
Binding residue
(residue number reindexed from 1)		K319 R321 C386 K387 A388 Q394
External links
PDB RCSB:8tas, PDBe:8tas, PDBj:8tas
PDBsum8tas
PubMed
UniProtQ15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

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