Structure of PDB 8rhq Chain E Binding Site BS01

Receptor Information
>8rhq Chain E (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHSMRYFYTSVSRPGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWI
EQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCD
VGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHA
AEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLR
CWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSG
EEQRYTCHVQHEGLPKPLTLRWE
Ligand information
>8rhq Chain I (length=10) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SVLNDIFSRL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rhq The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Y7 Y9 E63 N66 Q70 T73 D74 D77 T80 L81 I97 Y99 R114 D116 I142 T143 K146 W147 A152 Q155 Y159 R163 W167 Y171
Binding residue
(residue number reindexed from 1)		Y7 Y9 E61 N64 Q68 T71 D72 D75 T78 L79 I95 Y97 R112 D114 I140 T141 K144 W145 A150 Q153 Y157 R161 W165 Y169
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation

View graph for
Biological Process
External links
PDB RCSB:8rhq, PDBe:8rhq, PDBj:8rhq
PDBsum8rhq
PubMed38742159
UniProtQ5S3G3

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