Structure of PDB 8rh6 Chain E Binding Site BS01

Receptor Information
>8rh6 Chain E (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYG
CDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAA
HAAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRWE
Ligand information
>8rh6 Chain I (length=10) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SVLNDILSRL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rh6 The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific.
Resolution3.32 Å
Binding residue
(original residue number in PDB)		Y7 Y9 E63 A69 Q70 T73 D74 D77 I97 Y99 I142 T143 K146 W147 A152 Q155 Q156 Y159 R163 W167
Binding residue
(residue number reindexed from 1)		Y7 Y9 E63 A69 Q70 T73 D74 D77 I97 Y99 I142 T143 K146 W147 A152 Q155 Q156 Y159 R163 W167
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation

View graph for
Biological Process
External links
PDB RCSB:8rh6, PDBe:8rh6, PDBj:8rh6
PDBsum8rh6
PubMed38742159
UniProtQ5S3G3

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