Structure of PDB 8pw6 Chain E Binding Site BS01

Receptor Information
>8pw6 Chain E (length=196) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHTDVKVPDFSDYRRAEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYA
AKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRH
RTKKEIDQEAAVEVSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANA
GDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPAYEFTSDDVVVVG
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8pw6 Chain E Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8pw6 SCAF1 drives the compositional diversity of mammalian respirasomes.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C139 H141 L142 C144 C158 H161
Binding residue
(residue number reindexed from 1)		C139 H141 L142 C144 C158 H161
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.8: quinol--cytochrome-c reductase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0009410 response to xenobiotic stimulus
GO:0009725 response to hormone
GO:0022904 respiratory electron transport chain
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0043209 myelin sheath
GO:0045275 respiratory chain complex III

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pw6, PDBe:8pw6, PDBj:8pw6
PDBsum8pw6
PubMed38575788
UniProtQ9CR68|UCRI_MOUSE Cytochrome b-c1 complex subunit Rieske, mitochondrial (Gene Name=Uqcrfs1)

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