Structure of PDB 8kd4 Chain E Binding Site BS01

Receptor Information
>8kd4 Chain E (length=317) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKRPKRLSSQNVNYDLKRRKIITSEGIERSFKNENEDFCSACNQSGSFLC
CDTCPKSFHFLCLDPPIDPNNLPKGDWHCNECKFKIFINNSMATLKKIES
NFIKQNNNVKIFAKLLFNIDSHNPKQFQLPNYIKETFPAVKTGSRGQYSD
ENDKIPLTDRQLFNTSYGQSITKLDSYNPDTHIDSNSGKFLICYKCNQTR
LGSWSHPENSRLIMTCDYCQTPWHLDCVPRASFKNLGSKWKCPLHSPTKV
YKKINYKVWKKQRLINKKNQLYYEPLQKIGYQNNGNIQIIPDFKITQIDE
NSIKYDFFDKIYKSKMV
Ligand information
>8kd4 Chain Y (length=164) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccctggagaatcccggtgccgaggccgctcaattggtcgtagacagctct
agcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaa
ggggattactccctagtctccaggcacgtgtcagatatatacatcctgtt
ctagagcggccgcc
Receptor-Ligand Complex Structure
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PDB8kd4 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		T318 K320 R384
Binding residue
(residue number reindexed from 1)		T94 K96 R160
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006368 transcription elongation by RNA polymerase II
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060195 negative regulation of antisense RNA transcription
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0032221 Rpd3S complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kd4, PDBe:8kd4, PDBj:8kd4
PDBsum8kd4
PubMed37666978
UniProtQ04779|RCO1_YEAST Transcriptional regulatory protein RCO1 (Gene Name=RCO1)

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